Asian cobra venom for human medicine

Black mambas have deadly venom containing a mixture of toxins — and two proteins that block pain. With a series of swift bites, the black mamba injects a toxic cocktail that can kill a human within 20 minutes. The snake proteins — called mambalgins — were discovered as part of a search for alternatives to opiate drugs such as morphine. Many patients grow tolerant of opiates, requiring higher doses over time, and the drugs often cause side effects such as nausea, constipation and drug dependency. He and his colleagues identified the proteins from the black mamba Dendroaspis polylepis after testing about 50 different animal venoms.
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South Florida Company Turns Cobra Venom Into Healing Treatment

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Venoms in medicine: how we're turning to deadly venoms into cures - BBC Science Focus Magazine

Snake envenomation is a serious public health threat in the rural areas of Asian and African countries. To date, the only proven treatment for snake envenomation is antivenom therapy. Cross-neutralization of heterologous venoms by antivenom raised against venoms of closely related species has been reported. NPAV was produced by immunization against 4 Thai elapid venoms. In vitro neutralization study using mice showed that NPAV was able to neutralize effectively the lethality of venoms of most common Asiatic cobras Naja spp. Studies with several venoms showed that the in vivo neutralization potency of the NPAV was comparable to the in vitro neutralization potency. NPAV could also fully protect against N.
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Snake Venoms in Cancer Therapy: Past, Present and Future

Meera Senthilingam , for CNN. Vital Signs is a monthly program bringing viewers health stories from around the world. CNN They grow up to one meter in length and kill their prey using injections of venom.
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Geographical variations of snake venoms can result in suboptimal effectiveness of Indian antivenoms that are currently used in most South Asian countries. Our results suggest that optimal neutralization for Pakistani N. Bites by venomous snakes can result in envenomation, a life-threatening disease that is prevalent in many tropical and subtropical countries.
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